Recent insights into the molecular regulators and mechanisms of taurine to modulate lipid metabolism: a review

Abstract

Lipid metabolism disorders such as hypertriglyceridemia and hypercholesterolemia are risk factors for cardiovascular diseases and atherosclerosis that are grave public health issues. Taurine, a sulfur-containing non-essential amino acid exerts a wide range of physiological effects that regulate lipid metabolic disorders. Although the effects of taurine on lipid-lowering have been reported in animals and humans, mechanisms elucidating the lipid-lowering action of taurine remain unclear. A series of molecular regulators associated with lipid metabolism have been identified in the past few decades. These include nuclear receptors, transcription factors, and enzymes that undergo important changes during taurine treatment. In this review, we focus on the role of taurine in lipid metabolism and discuss taurine-related interventions in combating lipid disorders.

Keywords:

• Taurine
• hyperlipidemia
• lipid metabolism
• transcription factors
• molecular targets

Acknowledgements

The authors gratefully acknowledge the Director, CSIR-CFTRI, for her constant support and encouragement.

Disclosure statement

The authors have no potential conflict of interest to declare.