Advanced search
Publication Cover
Critical Reviews in Food Science and Nutrition Volume 63, 2023 - Issue 25
Submit an article Journal homepage
1,703
Views
11
CrossRef citations to date
0
Altmetric
Review Articles

The regulative effect and repercussion of probiotics and prebiotics on osteoporosis: involvement of brain-gut-bone axis

Yuan-Wei Zhanga Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-1026-833XView further author information
ORCID Icon,
Mu-Min Caoa Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaView further author information
,
Ying-Juan Lib Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;f Department of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-5580-1003View further author information
ORCID Icon,
Guang-Chun Daia Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaView further author information
,
Pan-Pan Lua Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-9751-2947View further author information
ORCID Icon,
Ming Zhanga Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-6032-7262View further author information
ORCID Icon,
Li-Yong Baia Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaView further author information
,
Xiang-Xu Chena Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaView further author information
,
Cheng Zhanga Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaView further author information
,
Liu Shia Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-8990-4019View further author information
ORCID Icon &
Yun-Feng Ruia Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;b Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;c School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China;d Orthopaedic Trauma Institute (OTI), Southeast University, Nanjing, Jiangsu, P.R. China;e Trauma Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9019-5531View further author information
ORCID Icon show all
Pages 7510-7528 | Published online: 02 Mar 2022
 
Sample our Environment & Agriculture journals, sign in here to start your access, latest two full volumes FREE to you for 14 days

Abstract

Osteoporosis (OP) is a systemic disease characterized by decreased bone mass and degeneration of bone microstructure. In recent years, more and more researches have focused on the close relationship between gut microbiota (GM) and the occurrence and progression of OP, and the regulation of probiotics and prebiotics on bone metabolism has gradually become a research hotspot. Based on the influence of brain-gut-bone axis on bone metabolism, this review expounds the potential mechanisms of probiotics and prebiotics on OP from next perspectives: regulation of intestinal metabolites, regulation of intestinal epithelial barrier function, involvement of neuromodulation, involvement of immune regulation and involvement of endocrine regulation, so as to provide a novel and promising idea for the prevention and treatment of OP in the future.

Authors’ contribution

YWZ, MMC, GCD, PPL, MZ, LYB, XXC, CZ and LS conducted the literature research and synthetized information. YWZ wrote the manuscript. LS, YJL and YFR revised the whole manuscript. All authors read and approved the final version of the manuscript for publication.

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Funding

This research received no specific grant from any funding agency, commercial or not-for-profit sector.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 440.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.