Multifaceted chemistry of 2-phosphaindolizines

Abstract

A good number of 2-phosphaindolizines, i.e. 1,3-azaphospholo[1,5-a]pyridines could be prepared from two synthetic methods, namely [4 + 1] cyclocondensation and via 1,5-electrocyclization. These compounds incorporate several functionalities, which subsequently react with appropriate reagents to make a wide variety of organophosphorus compounds including co-ordination compounds available. Thus, multifaceted chemistry could be developed around 2-phosphaindolizines. In the present overview, 1,2-additions including Diels-Alder (DA) reactions across the > C = P- functionality, electrophilic substitutions and co-ordination of the phosphorus atom to the metal carbonyls are described.

GRAPHICAL ABSTRACT

Keywords:

• Bromination
• co-ordination compounds
• DFT calculations
• Diels-Alder reaction
• 2-phosphaindolizines
• reactivity of > C=P- bond