Synthesis of functionalized selenazole derivatives via a three-component condensation of ethyl-2-chloro-3-oxo-butyrate, potassium selenocyanate and hydrazine or hydrazide derivatives

Abstract

A simple, one-pot synthesis of five highly functionalized selenazole derivatives has been achieved in moderate-to-good yields via a three-component condensation of ethyl-2-chloro-3-oxo-butyrate, potassium selenocyanate and various substituted hydrazines or hydrazides in acetone at room temperature.

Graphical Abstract

Keywords:

• Ethyl-2-chloro-3-oxo-butyrate
• hydrazines
• hydrazides
• potassium selenocyanate
• functionalized selenazole derivatives
• three-component condensation