Transition metal complexes of α-aminophosphonates part II: Synthesis, spectroscopic characterization, and in vitro anticancer activity of copper(II) complexes of α-aminophosphonates

Abstract

A one pot procedure was used to synthesize two new derivatives of α-aminophosphonates. Novel copper(II) complexes of α-aminophosphonates were synthesized by coordinating different copper salts with the newly synthesized α-aminophosphonates. Their structures were characterized by different spectral and analytical techniques. Evaluation of the metal-free ligands HL1, HL², and their Cu(II) complexes against human colon carcinoma HT-29 cell lines was performed, using cisplatin as a reference drug. The results indicated that the complexes of the ligand HL¹ exhibited enhanced anticancer activity, while ligand HL² complexes showed decreased anticancer activity.

Graphical Abstract

Keywords:

• α-Aminophosphonates
• copper(II) complexes
• spectroscopic characterization
• anticancer activity

Acknowledgments

The authors would like to thank Professor Masaharu Seno research team, Division of Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Japan, for their help with the in vitro anticancer activity.