Green approaches for the synthesis of nucleotides, their conjugates and analogues

Abstract

We have developed original one-pot and protecting group-free approaches, which are also user-friendly and reliable, to synthesize nucleotides and derivatives starting from nucleoside 5’-monophosphates. Both methods present convenient set-up, i.e., non-dry solvents and reagents, substrates in their sodium or acid form, and commercially available and cheap phosphorus reagents as sodium and potassium salts.

GRAPHICAL ABSTRACT

Keywords:

• Organophosphorus chemistry
• nucleotides
• dinucleotides
• water chemistry
• mechanochemistry