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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 197, 2022 - Issue 5-6: ICPC-23: 23rd International Conference on Phosphorus Chemistry; Guest Editors:Professor Jozef Drabowicz; Professor Piotr Kiełbasiński and Professor Tomasz Cierpiał
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Synthesis and antimicrobial activity of phosphorylated betaines

Aidar Gayneeva A. M. Butlerov Chemical Institute, Kazan Federal (Volga Region) University, Kazan, RussiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7539-1937View further author information
ORCID Icon,
Rustam Davletshina A. M. Butlerov Chemical Institute, Kazan Federal (Volga Region) University, Kazan, RussiaORCID Iconhttps://orcid.org/0000-0002-1708-6985View further author information
ORCID Icon,
Irina Galkinaa A. M. Butlerov Chemical Institute, Kazan Federal (Volga Region) University, Kazan, RussiaORCID Iconhttps://orcid.org/0000-0003-1035-3427View further author information
ORCID Icon,
Natal’ya Davletshinaa A. M. Butlerov Chemical Institute, Kazan Federal (Volga Region) University, Kazan, RussiaORCID Iconhttps://orcid.org/0000-0003-0231-337XView further author information
ORCID Icon,
Andrey Sedova A. M. Butlerov Chemical Institute, Kazan Federal (Volga Region) University, Kazan, RussiaView further author information
,
Milyausha Mirkhuzinaa A. M. Butlerov Chemical Institute, Kazan Federal (Volga Region) University, Kazan, RussiaView further author information
,
Evgeniy Kuchaeva A. M. Butlerov Chemical Institute, Kazan Federal (Volga Region) University, Kazan, Russia;b Laboratory for Structural Analysis of Biomacromolecules, Kazan Scientific Center of Russian Academy of Sciences, Kazan, RussiaView further author information
&
Daut Islamova A. M. Butlerov Chemical Institute, Kazan Federal (Volga Region) University, Kazan, Russia;b Laboratory for Structural Analysis of Biomacromolecules, Kazan Scientific Center of Russian Academy of Sciences, Kazan, RussiaORCID Iconhttps://orcid.org/0000-0002-5988-1012View further author information
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Pages 654-656 | Received 23 Nov 2021, Accepted 17 Dec 2021, Published online: 31 Jan 2022
 
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Abstract

Target phosphorylated betaines (1–3) were obtained by the quaternization reaction between potassium salt of amino phosphonate and alkyl halides. The structures of the compounds were investigated by IR and NMR spectroscopy. The molecular structure of isopropyl [(N-octyl-N,N-diethylammonio)methyl]phosphonate (2) was determined by a single crystal X-ray analysis. Compound 2 demonstrates a high antibacterial activity against bacterial strain Staphylococcus epidermidis.

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The reported study was funded by RFBR according to the research project No. 20-33-90255.

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