An overview on synthetic routes of anti-inflammatory active scaffolds including thiazole and thiazolidine cores

Abstract

Thiazoles and thiazolidines are widespread occurring in natural products. They act as a viaduct between medicinal and organic chemistry. The presence of sulfur elevates their pharmacological activities whereas the presence of nitrogen makes it an active moiety for the development of scaffolds in a drug discovery process. Therefore, both of these compounds can be utilized as a vehicle for the synthesis of beneficial organic amalgamation. Thiazole exhibits high curative properties which enabled researchers to focus on composing various attempts to integrate and investigate novel structural precursors, which are more effective. On the other hand, thiazolidine and its derivatives are used in scrutinizing drug designs for the development of multifunctional drugs and modifying their activity. Both the nucleus and their derivative are blended in the evolution of drugs that display selective inhibition of both types of cyclooxygenases as well as lipoxygenase enzymes. In the present review, different recent synthetic routes of this important class are presented which show anti-inflammatory activities and enhanced potential in the inhibition of COX enzymes.

Graphical Abstract

Keywords:

• Thiazole
• thiazolidine
• anti-inflammatory
• COX enzymes
• pharmacological activities

Acknowledgment

The authors gratefully acknowledge the University College of Science, Mohanlal Sukhadia University, Udaipur, Rajasthan, India for essential research and library facilities for carrying out the work.

Disclosure statement

The author declares no conflict of interest.

Additional information

Funding

This work is ostensibly supported by University Grants Commission for UGC-Start-Up Project (No. F. 30-476/2019 (BSR)) and also thankful to RUSA 2.0 of MHRD for the project no. F30(16) SPD/RUSA/2016/178. And also supported by Rashtriya Uchchatar Shiksha Abhiyan.