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Leukemia & Lymphoma Volume 60, 2019 - Issue 10
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Original Articles

Limited stage grade 3 follicular lymphoma patients can experience favorable outcomes with combined modality therapy

Zeina AyoubDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-8484-7812
ORCID Icon,
Therese AndraosDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Sarah A. MilgromDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Chelsea C. PinnixDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; ORCID Iconhttp://orcid.org/0000-0003-3982-3664
ORCID Icon,
Bouthaina S. DabajaDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Sweet Ping NgDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Jillian R. GuntherDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Joseph D. KhouryDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Nathan H. FowlerDivision of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USAORCID Iconhttp://orcid.org/0000-0002-9494-1877
ORCID Icon,
Satva S. NeelapuDivision of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Felipe SamaniegoDivision of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA
,
Luis E. FayadDivision of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA
&
Loretta J. NastoupilDivision of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA
 show all
Pages 2432-2440 | Received 21 Oct 2018, Accepted 10 Mar 2019, Published online: 03 Apr 2019
 
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Abstract

Controversy exists regarding the optimal management of limited stage grade 3 follicular lymphoma (FL3). We assessed the treatment outcomes of 190 consecutive patients with stage I-II FL. Fifty two patients had FL3 disease, in whom the median age was 55 years. At a median follow-up of 65 months, 5-year progression-free survival (PFS) and overall survival (OS) rates were 76.6% and 87.6%, respectively. Patients receiving systemic therapy followed by radiation therapy (RT) had a significantly better PFS (p=.003) than those treated with RT alone, but similar OS (p = .476). Patients treated with RT had 100% local control. Compared to 132 patients with grade 1–2 FL, those with FL3 had similar PFS (p = .493) and OS (p  =  .330). Patients with FL3 can experience favorable outcomes when treated with a combination of systemic therapy and RT, comparable to low grade FL.

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