Molecular- and cytogenetic characterization of the IGH associated t(1;14) in a nodal marginal zone B-cell lymphoma case

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Acknowledgement

We want to thank Marianne Klokow and Anna Schellenberg for excellent technical assistance. We are grateful to our patient for her valuable donation for science purposes.

Ethical approval

Patients’ specimens were collected in diagnostic units for haematological malignancies in the context of routine diagnostics and only surplus material was analyzed for the study. Informed consent was obtained from the patient in accordance to local laws approved by the local ethic committees for collecting and archiving their surplus material for further experimental studies in the participating institutes. The study has been performed in accordance with the Helsinki declaration of 1975, as revised in 2000.

Disclosure statement

The authors declare no potential conflict of interest.

Author contributions

Contributions: N.A. designed and supervised the study, performed experiments, analyzed data, and wrote the manuscript. E.M.M.P. performed experiments and revised the manuscript. S.J. wrote the manuscript. S.L. supplied material. C.B. critically revised the manuscript. J.D. supervised the study and wrote the manuscript.

All authors have read and reviewed the manuscript.

Data availability statement

Sequences covering the translocation breakpoints at der(1) and der(14) are submitted to NCBI with the gene bank accession numbers MW330382 and MW330383, respectively.

Additional information

Funding

This work was supported by the “Deutsche Krebshilfe” grant 109098, (J.D.).