Local asymptotic inference for nonparametric regression with censored survival data

Abstract

We consider a penalised nonparametric estimation of the relative risk function in the Cox proportional hazards model for survival data with right censoring. We derive the convergence rate, functional Bahadur representation (FBR) and local asymptotic normality of the nonparametric estimator by using reproducing kernel Hilbert space, counting process and empirical process theory. The new theoretical results fill the gap in the smoothing splines literature for nonparametric estimation in survival models. Furthermore, we construct the corresponding local confidence intervals by the bootstrap method. Extensive simulation studies are conducted to validate the proposed method and compare with the Bayesian confidence intervals, and a data example from the Stanford heart transplant study is provided for illustration.

Keywords:

• Censored survival data
• Cox proportional hazards model
• functional Bahadur representation
• nonparametric statistical inference
• reproducing kernel Hilbert space

2010 Mathematics Subject Classifications:

• 62N01
• 62N02
• 62N86
• 62G86

Acknowledgments

This work is supported in part by grants from the National Science Foundation of China (Grants No. 11771366, 11571263, 11971362).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work is supported in part by grants from the National Science Foundation of China (Grants No. 11771366, 11571263, 11971362).