Investigation of Genetic Effects of Nucleotide Variants Within the Goat PRNT Gene on Growth Performance

Abstract

Our previous study has firstly pointed that three nucleotide variants (g.−11C > T, g.117A > G, and g.149C > T) of the goat PRNT gene can significantly influence litter size. Given litter size is positively correlated with growth performance, we consider whether the PRNT gene also acts on the growth performance in goats. In this work, a correlation analysis among different litter size types and growth traits of Shaanbei white cashmere (SBWC) goats was performed, and results showed that a positive correlation did exist in our detected population (P < 0.01). Then, the association among different genotypes of three variations and goat growth performance was measured. Our results pointed to g.117A > G being significantly associated with the cannon circumference (P = 4.60E-05) while no significant effect was found between another two SNPs and growth traits after the Bonferroni’s correction (P*n < 0.05). Together, this is the first report about the influence of the PRNT gene on the growth of goat and g.117A > G can be regarded as a possible DNA marker applying for MAS breeding.

Keywords:

• Goat
• PRNT
• growth trait
• single nucleotide polymorphism

Acknowledgements

We thank to the Ph.D. Prof. Lei Qu and his team at Yulin University for providing samples. We also thank to Agricultural Technical Station of Veterinary and Animal Husbandry of Yulin City, Shaanxi Province, P.R. China, the Life Science Research Core Services (LSRCS) of Northwest A&F University (Northern Campus), and the college of veterinary medicine of Northwest A&F university, for providing us with the platform.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by National Natural and Science Foundation of China [No.32060734; No.31760650].