Fluorinated sodium carboxymethyl cellulose nanoparticles as carrier for improving adhesion and sustaining release of AVM

Abstract

The loss and overuse of avermectin (AVM) on protecting plants pose a threat to ecosystems. To increase the efficacy of AVM, fluorinated sodium carboxymethyl cellulose (CMC-g-PHFBA) was synthesized by inducing poly 2, 2, 3, 4, 4, 4-hexafluorobutyl methacrylate (HFBA), and AVM was then enveloped in CMC-g-PHFBA (AVM@CMC-g-PHFBA) via hydrophobic interaction. According to the results, the samples exhibited desirable angle contact (min = 58.18°), retention rate (max = 60%, after water washing) and LHC (15.5 mg/cm²) on cucumber leaves. AVM@CMC-g-PHFBA also showed good storage stability with obvious Tyndall effect (size <240 nm and charge <–21 mV) for 11 days, with higher anti-UV property. The loaded AVM nanoparticles can release drugs for 95 h, which can be fitted to a zero-order model under different pH conditions for achieving a prolonged pharmacological action. Moreover, the samples have retained insecticidal activity. Collectively, CMC-g-PHFBA nanoparticles are promising delivery systems of AVM with the adhesive and sustained-release property.

GRAPHICAL ABSTRACT

Keywords:

• Fluorinated CMC
• avermectin
• nanoparticles
• adhesion
• sustained-release

Disclosure statement

The authors declare no competing financial interest.

Additional information

Funding

The authors gratefully appreciate the financial support from Science Technology Program of Guangzhou, China [grant no. 201903010011], Innovation Team of Modern Agricultural Industry Technology System of Guangdong Province [grant no. 2019KJ140], Innovation Team Project by the Department of Education of Guangdong Province [grant no. 2018KCXTD015].