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Research Article

Amide-Linked Dendron-based Amphiphiles: A class of pH sensitive and highly biocompatible drug carrier for sustained drug release

ORCID Icon, , & ORCID Icon
Pages 211-221 | Received 09 Jun 2021, Accepted 25 Jul 2021, Published online: 15 Oct 2021
 

ABSTRACT

PG-dendritic amide-linked amphiphilic micelles were studied to increase the solubility of hydrophobic molecules. The encapsulation study was done by utilising hydrophobic pyrene dye using U.V. technique. The encapsulation efficiency of the non-ionic amphiphiles was obtained at neutral p.H. and at room temperature (p.H. 7.0 & 28 °C). The G.3 dendron-based non-ionic oleic (C18-cis)-amphiphile was found to have the 78.2% encapsulation efficiency. Studies show that the amide-linked G.1 dendron-based non-ionic (C18-cis) amphiphiles have sustained dye release percentage of 78.00% at p.H. 6.2 and 26.19% at p.H. 7.0 in 72 h at 37 °C. The in vitro cyto-toxicological studies showed that after 24–48 h treatment, the G.1 amide amphiphiles exhibit more than 80% of cell viability for concentration as high as 31.25 μg/mL. The cellular uptake was demonstrated using Coumarin 6. The integrated amphiphiles are biocompatible and can be used in the biomedical field as medication encapsulation and target drug delivery.

Graphical abstract

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Guru Gobind Singh Indraprastha University [FRGS].

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