Synthesis of novel fused acenaphtopyrimidine hybrid, its photophysical properties and HSA interaction

ABSTRACT

A facile and versatile procedure for the synthesis of novel functionalised 10-(1H-indol-3-yl)acenaphtho[1,2-d]pyrimidin-8-amine (compound 4) has been described. The novel intermediate enone (3) and pyrimidine derivatives (4) were characterised by using FT-IR, NMR and MS. Moreover, the photophysical properties of compound 4 and its interaction with HSA (Human Serum Albumin) have been investigated by means of photometric and fluorimetric titration. Compound 4 showed the increase in fluorescence and hypsochromic shift of its maximum upon the addition of HSA that interaction is supported by molecular docking. Overall, Compound 4 has promising affinity towards HSA which was not previously reported for any fused acenaphtenone–pyrimidine hybrid analogues.

Graphical abstract

KEYWORDS:

• HSA interaction
• fused heterocyclic compounds
• photophysical properties
• acenaphtopyrimidine derivatives
• solvatochromism

Acknowledgments

I specially thank Prof. Dr. Zeynel SEFEROĞLU, Assoc. Prof. M. Gökhan ÇAĞLAYAN and F. Metehan BENLI for the help and support in the interaction studies.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Supplementary Material

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