Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia

ABSTRACT

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors.

Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12–19, 20–29, 30–34 and 35–40 weeks of gestation.

Results: D-Di was lower at 12–19 weeks and higher at 30–34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn’t differ between groups.

Conclusion: D-Di was able to discriminate these groups of women at 12–19 and 30–34 weeks of gestation.

KEYWORDS:

• Preeclampsia
• D-dimer
• PAI-1
• longitudinal study
• hypercoagulability

Acknowledgments

The authors thank the researchers from the Fetal Medicine Center at Clinical Hospital/Federal University of Minas Gerais, who were essential to this study. LMSD and AT are grateful for CNPq fellowship.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by FAPEMIG under Grant #00764-16 and CNPq/Brazil under Grant #404353/2016-9.