The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis

ABSTRACT

Objective: The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia.

Methods: Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model.

Results: The pooled SMD between case and control was 1.40 (95% CI: 0.26, 2.55; P = 0.02). And the pooled SMD between mild PE and severe PE was 5.25 (95% CI: 1.5, 9.01; P = 0.006).

Conclusion: The meta-analysis illustrated that melatonin concentration was significantly lower in women with preeclampsia, and correlated with the severity of the disease.

KEYWORDS:

• Melatonin
• preeclampsia
• pathogenesis
• pregnancy
• meta-analysis

Acknowledgments

The authors would like to thank Professor Lu for his guidance and instructive advice.

Disclosure statement

No potential conflict of interest was reported by the authors.

Supplementary material

Supplemental data can be accessed here.

Additional information

Funding

This work was supported by the the University Science Research Project of Jiangsu Province [16KJB330009]; the Chinese National Nature Science Foundation [81473008, 81673203, 81803271, 81573173, 81402626].