Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction

ABSTRACT

Objective: To evaluate longitudinal changes of angiogenic biomarkers in early- (EO-PD) versus late-onset (LO-PD) placental dysfunction.

Methods: Serum PlGF and sFlt-1 measured at different intervals in EO-PD (n= 43), LO-PD (n= 31) and controls (n = 133).

Results: sFlt-1/PlGF ratio was higher at 16 weeks (30.6 vs 17.5), 20 weeks (29.3 vs 8.9) and 30 weeks (16.6 vs 6.7) in EO-PD vs controls (all p< 0.05), but not in LO-PD. Longitudinal changes for all intervals had higher AUC than single measurements.

Conclusion: Longitudinal biomarker change between 12 and 30 weeks could improve prediction of EO-PD compared to single measurements.

KEYWORDS:

• Early Pregnancy Complications
• Eclampsia
• HELLP
• High-Risk Pregnancy
• Pregnancy induced Hypertension
• Placenta
• Preeclampsia
• Fetal Growth Restriction

Data availability statement

The dataset used and analyzed during the current study is available from the corresponding author, [email protected], upon reasonable request.

Disclosure statement

No potential conflict of interest was reported by the authors.