Association of Apolipoprotein E gene polymorphism with Preeclampsia: a meta-analysis

ABSTRACT

Objective

The aim of this meta-analysis was to examine the association of ApoE polymorphism with the risk of developing PE.

Methods

A comprehensive search was carried out through PubMed, Scopus, and Embase. The ORs with corresponding 95% CIs were extracted. Fixed model was used for meta-analysis and in case of existing heterogeneity a random-effects model was applied.

Results

Association of ApoE polymorphism with the risk of developing PE was not statistically significant (OR = 0.86, 95% CI: 0.67–1.11; OR = 0.92, 95%CI: 0.73–1.15, respectively for ε2 and ε4).

Conclusion

ApoE polymorphism might not be associated with the risk of PE.

KEYWORDS:

• Apolipoprotein E
• polymorphism
• preeclampsia
• meta-analysis

Author Contributions

Sakineh Shab-bidar and Morteza Abyadeh designed this study; Morteza Abyadeh and Fatemeh Heydarinejad extracted the data; Morteza Abyadeh and Maliheh khakpash performed the data analysis; Morteza Abyadeh and Yaser Asefi prepared the manuscript.

Disclosure statement

The authors report no conflict of interest.

Additional information

Funding

The authors received no specific funding for the research.