Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles

ABSTRACT

Objective: To detect the role of endothelial progenitor cells (EPCs) treated with platelet microparticles (PMPs) in preeclampsia.

Methods: EPCs treated with/without PMPs were labeled and injected to PE rats. The differentiation of EPCs, the change of endothelial nitric oxide synthase (eNOS), blood pressure and proteinuria were measured. The blood pressure and proteinuria increased in each of PE groups, and were improved by EPCs which was strengthened by PMPs. Transplantation of EPCs increased placental angiogenesis. The trend of change of NO was the same as blood pressure.

Conclusion: Transplantation of EPCs treated with PMPs improved blood pressure and proteinuria more effectively.

KEYWORDS:

• Platelet microparticles
• endothelial progenitor cells
• preeclampsia
• endothelial nitric oxide synthase

Acknowledgments

The authors would like to thank Shuhong An at the Taishan Medical College for assisting during the rat PE modeling.

Disclosure statement

The authors declare no conflicts of interest.

Additional information

Funding

The research was supported by the National Natural Science Foundation of China (Grant Nos. 81571461)