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Hypertension in Pregnancy Volume 40, 2021 - Issue 3
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Research Article

Does multiple sclerosis increase the risk of preeclampsia? A systematic review and meta-analysis

Ahmed Arafaa Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan;b Department of Public Health, Faculty of Medicine, Beni-Suef University, Beni-Suef, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3335-2243
ORCID Icon,
Xiaowen Wanga Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
,
Jia-Yi Donga Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
&
Ehab S Eshaka Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan;c Department of Public Health, Faculty of Medicine, Minia University, El-Minya, Egypt
Pages 180-185 | Received 23 Dec 2020, Accepted 20 Apr 2021, Published online: 17 May 2021
 
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ABSTRACT

Objective: We investigated, via systematic review and meta-analysis, whether multiple sclerosis (MS) is associated with the risk of preeclampsia (PE).

Methods: From the eligible studies, we pooled odds ratios (ORs) and confidence intervals (CIs) of PE for pregnant women with MS compared with pregnant women without it using the fixed-effects model. The I2 measured heterogeneity between studies.

Results: Eight eligible studies (9 cohorts) were included. Pregnant women with MS had no excess risk of PE compared with pregnant women without MS (pooled OR = 0.99, 95% CI: 0.89, 1.09; I2 = 0.00%).

Conclusion: MS is not associated with PE.

Disclosure statement

No potential conflict of interest was reported by the authors.

Supplementary material

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