Increased expression of lncRNA SNHG7 promotes the cell viability, migration, and invasion in pre-eclampsia via modulating the miR-214-5p/TWIST1 axis

ABSTRACT

Purpose

This study is aimed to elucidate the molecular mechanism of lncRNA SNHG7 on pre-eclampsia (PE).

Methods

The expression of SNHG7, miR-214-5p and TWIST1 in PE placental tissues was detected by qRT-PCR. The regulatory mechanism of SNHG7/miR-214-5p/TWIST1 axis on PE was determined using MTT, wound healing, transwell invasion, and western blot assays.

Results

In PE pregnancies, SNHG7 and TWIST1 were decreased, while miR-214-5p was increased.The elevated miR-214-5p and decreased TWIST1 partly eliminated the promoting effects of SNHG7 up-regulation on the viability and metastasis of JEG-3 cells.

Conclusions

Up-regulated SNHG7 protects against PE through modulating the miR-214-5p/TWIST1 axi.

KEYWORDS:

• Pre-eclampsia
• lncRNA snhg7
• miR-214-5p
• twist1

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported that there is no funding associated with the work featured in this article.