MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway

ABSTRACT

Animal experiments showed that PIH rats had increased mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP), but decreased litter size, number of viable fetuses, fetal weight, and placental weight. The higher Flt-1 and lower VEGF was observed in PIH rats with elevated TNF-α and IL-6 levels and decreased IL-10 levels. Treatment with agomiR-140-5p improved regarding the above indicators. Cell experiments demonstrated that miR-140-5p mimic increased cell invasion and migration abilities and decreased the activity of TGF-β/Smad pathway, while TGFBR1 can reverse the role of miR-140-5p mimic in trophoblasts.

KEYWORDS:

• miR-140-5p
• pregnancy-induced hypertension
• TGF-β/Smad pathway
• TGFBR1

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability

All relevant data are within the study.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.