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Journal of Chemotherapy Volume 32, 2020 - Issue 2
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Brief Communication

Extensively-drug resistant Acinetobacter baumannii bacteremia in neonates: effective treatment with the combination of colistin and ampicillin/sulbactam

Despoina GkentziDepartment of Pediatrics, University General Hospital of Patras, Patras Medical School, Rio, Greece; Correspondence[email protected]
,
Asimina TsintoniDepartment of Pediatrics, University General Hospital of Patras, Patras Medical School, Rio, Greece;
,
Irini ChristopoulouDepartment of Pediatrics, University General Hospital of Patras, Patras Medical School, Rio, Greece;
,
Ilias MamalisDepartment of Pediatrics, University General Hospital of Patras, Patras Medical School, Rio, Greece;
,
Fotini PaliogianniDepartment of Microbiology, University General Hospital of Patras, Patras Medical School, Rio, Greece;
,
Stelios F. AssimakopoulosDepartment of Infectious Diseases, University General Hospital of Patras, Patras Medical School, Rio, GreeceORCID Iconhttp://orcid.org/0000-0002-6901-3681
ORCID Icon,
Markos MarangosDepartment of Infectious Diseases, University General Hospital of Patras, Patras Medical School, Rio, Greece
&
Gabriel DimitriouDepartment of Pediatrics, University General Hospital of Patras, Patras Medical School, Rio, Greece;
show all
Pages 103-106 | Received 24 Oct 2019, Accepted 08 Jan 2020, Published online: 29 Jan 2020
 
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Abstract

Acinetobacter baumannii has evolved as a major pathogen of outbreaks in the healthcare setting with increased morbidity and mortality. In neonates, treatment can be quite challenging due to the resistance profile of A. baumannii as well as limited data on pharmakokinetics and pharmakodynamics of antibiotics in this age group. We present an outbreak of eight cases of extensively-drug resistant (XDR) A. baumannii bacteremias successfully managed with the combination of colistin with high dose ampicillin/sulbactam.

Disclosure statement

No potential conflict of interest was reported by the authors.

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