Abstract
Pseudomonas aeruginosa has become a significant health threat, as it has developed resistance to multiple antimicrobial drugs. In this study, we aimed to identify class 1, 2 and 3 integrons in clinical P. aeruginosa isolates for the first time in Egypt, and detect their relationship with antibiotic resistance. A total of 192 clinical P. aeruginosa isolates were gathered from Tanta University Hospitals. One hundred and thirteen isolates (58.9%) were multidrug- resistant, and 38 isolates (19.8%) were resistant to all drugs tested. Class 1 integrons were detected in 87 isolates (45.3%), while class 2 and 3 integrons were not detected. This is the first report of a profile of integrons in P. aeruginosa from Egypt. The detection of only class 1 integrons in our isolates suggests that other genetic elements may be responsible for the distribution of antibiotic resistance in our setting. Aztreonam and colistin were the drugs of choice for the treatment of infections with P. aeruginosa.
Acknowledgments
We would like to thank the staff of the Laboratories of Tanta University Hospitals for their help in collecting the isolates incorporated in this study. This study was performed at the Faculty of Medicine, Tanta University, Egypt.
Disclosure statement
No potential conflict of interest was reported by the authors.
Availability of data and material
The datasets used in the present study are available from the corresponding author on reasonable request