ABSTRACT
Introduction: Relationships between subjective cognitive functioning (SCF), objective cognitive functioning (OCF), and depressive symptoms are poorly understood in treatment-resistant psychosis (TRP). This study (a) compares SCF in TRP using positively and negatively worded scales, (b) assess these scales’ accuracy, and (c) explores the association between these scales and depressive symptoms. We hypothesised that both SCF scales would be highly correlated, minimally associated with OCF, and similarly associated with depressive symptoms. Methods: Archival clinical data from 52 TRP inpatients was utilised. OCF composite scores were derived from a broad neuropsychological battery. SCF was assessed using the norm-referenced PROMIS 2.0 Cognitive Abilities (positively worded) and Concerns (negatively worded) subscales. A depressive symptom score was derived from the Positive and Negative Syndrome Scale. Results: SCF ratings were higher in patients than OCF. There was a small but significant correlation between PROMIS subscales (r = .30). Neither PROMIS subscale was associated with OCF (r = −.11, r = .01). Depressive symptoms were correlated with the positively (r = −.29) but not negatively worded scale (r = −.13). Conclusion: Individuals with TRP inaccurately rate their cognitive functioning and tend to overestimate their ability. Positively and negatively worded SCF scales associate variably with depressive symptoms, indicating they may not be used interchangeably in TRP.
Acknowledgements
The authors would like to acknowledge the BC Psychosis Program which provided the clinical data for this study.
Disclosure statement
IJT has served as consultant for Community Living British Columbia. RP has received consulting fees or sat on paid advisory boards for Janssen, Lundbeck and Otsuka; is on the speaker's bureau for Janssen, Lundbeck and Otsuka. RW has received honoraria from HLS Therapeutics for advisory panel activities, and from Canadian Agency for Drugs and Technology in Health as a consultant. WGH has served as a consultant for AbbVie.
Data availability statement
Due to the nature of this research, no supporting clinical data is available.
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Notes on contributors
Daniah Zumrawi
Daniah Zumrawi is a Research Assistant in the Department of Psychiatry at the University of British Columbia.
Brianne L. Glazier
Dr Brianne L. Glazier is a psychologist who works for Island Health in Mental Health and Substance Use Services.
Olga Leonova
Olga Leonova MD, PhD is a Research Associate at the Department of Psychiatry of the University of British Columbia.
Mahesh Menon
Mahesh Menon is a Clinical Professor in the Department of Psychiatry and clinical psychologist in the BC Psychosis Program at UBC Hospital.
Ric Procyshyn
Ric Procyshyn is a Clinical Professor of Psychiatry at University of British Columbia and Investigator within British Columbia Mental Health and Substance Use Services.
Randall White
Randall F. White is a Clinical Professor of Psychiatry at University of British Columbia and Clinical Director of the BC Psychosis Program at UBC Hospital.
Robert Stowe
Robert Stowe is a Clinical Professor of Psychiatry and Neurology at University of British Columbia, and a behavioral neurologist within the BC Neuropsychiatry Program.
William G. Honer
William G. Honer is Professor and Jack Bell Chair in Schizophrenia at the University of British Columbia, and Investigator within the British Columbia Mental Health and Substance Use Services Research Institute.
Ivan J. Torres
Ivan J. Torres is a Clinical Professor of Psychiatry at University of British Columbia and Investigator within British Columbia Mental Health and Substance Use Services.