The role of cognitive function and physical activity in physical decline in older adults across the cognitive spectrum

ABSTRACT

Objectives: The aim of this study was to investigate physical decline over 1-year in a cohort of older people across the cognitive spectrum.

Methods: Physical function was assessed using the Physiological Profile Assessment (PPA) in 593 participants (cognitively normal [CN]: n = 342, mild cognitive impairment [MCI]: n = 77, dementia: n = 174) at baseline and in 490 participants available for reassessment 1-year later. Neuropsychological performance and physical activity (PA) were assessed at baseline.

Results: Median baseline PPA scores for CN, MCI and dementia groups were 0.41 (IQR = −0.09–1.02), 0.66 (IQR = −0.06–1.15) and 2.37 (IQR = 0.93–3.78) respectively. All baseline neuropsychological domains and PA were significantly associated with baseline PPA. There were significant interaction terms (Time × Cognitive Group, Global Cognition, Processing Speed, Executive Function and PA) in the models investigating PPA decline. In multivariate analysis the Time × Executive Function and PA interaction terms were significant, indicating that participants with poorer baseline executive function and reduced PA demonstrated greater physical decline when compared to individuals with better executive function and PA respectively.

Discussion: Having MCI or dementia is associated with greater physical decline compared to CN older people. Physical inactivity and executive dysfunction were associated with physical decline in this sample, which included participants with MCI and dementia. Both factors influencing physical decline are potentially amenable to interventions e.g. exercise.

KEYWORDS:

• Cognitive impairment
• dementia
• mild cognitive impairment
• physical decline
• accidental falls

Acknowledgments

We are grateful to Dr. Stefanie Mikolaizak, Dr. Mellissa Slavin, Dr. Simone Reppermund, Dr. Kristan Kang, Dr. Julian Trollor and Dr. John Crawford for their contributions. We thank our research participants.

Disclosure statement

The PPA (NeuRA FallScreen) is commercially available through Neuroscience Research Australia. The Incidental and Planned Exercise Questionnaire (IPEQ) is available as a not-for-profit iPad application through Neuroscience Research Australia (NeuRA).

Additional information

Funding

This study was supported by the National Health and Medical Research Council (NHMRC) Cognitive Decline Partnership Centre and by NHMRC [grant number 400 941], [grant number 350 833] and [grant number 455 368]. This manuscript does not reflect the views of the NHMRC or funding partners. Dr. Morag Taylor is a NHMRC-Australian Research Council Dementia Research Development Fellow. A/Prof Kim Delbaere is a NHMRC Career Development Fellow. Prof Stephen Lord is a NHMRC Senior Principal Research Fellow.