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ABSTRACT
Aims
To investigate the effects of depression on cognitive function in patients of different ages with diabetes mellitus (DM).
Methods
6,549 patients with DM who were assessed using the Mini-Mental State Examination (MMSE) and Self-Rating Depression Scale (SDS) in 2016 were selected from the 2016 Kailuan Group staff physical examinations. Generalized linear regression models were used to analyze the effects of SDS index score on MMSE score in DM patients in different age groups. We also analyzed the effects of SDS index score on MMSE score in DM patients with different risk factors.
Results
Generalized linear regression analysis showed that higher SDS index score was associated with lower MMSE score (β = −0.06; P < 0.01). In addition, there was an interaction effect between SDS index score and age groups on cognitive function. Meanwhile, SDS index score also has an interaction effect with level of education.
Conclusions
The negative association between the degree of depression and cognitive function level increases with age in DM patients.
Acknowledgments
We thank Benjamin Knight, MSc., from Liwen Bianji (Edanz) (www.liwenbianji.cn) for editing the English text of a draft of this manuscript.
Disclosure statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Author contributions
Mingjie Yin was responsible for the conception and design of the study. Mingjie Yin and Xiaoyu Xu extracted the data, and conducted the statistical analyses. Mingjie Yin drafted the whole manuscript with the support of Hui Fang and Shouling Wu. All authors have materially participated the article preparation and approved the final manuscript.