Differential effect of high-fat, high-sucrose and combined high-fat/high-sucrose diets consumption on fat accumulation, serum leptin and cardiac hypertrophy in rats

Abstract

The consumption of high calorie-content diets is the first cause of obesity, probably the main health issue worldwide; however, the experimental evidences for evaluating the differential metabolic modifications of high-sucrose or high-fat diets are scare. We evaluated the metabolic outcomes of the obesity induced by the chronic consumption of high-sucrose (HS), high-fat (HF) or combined diets (HSHF), among the effect on the development of cardiac hypertrophy in Wistar rats. Rats from the HS, HF, and HSHS groups developed moderate obesity. Only the HS group showed increased triglycerides levels after four months. Increased leptin levels were observed in HS and HF groups without changes on cardiac hypertrophy; on the opposing, HSHF group presented hypertrophy without the changes in serum leptin. The three experimental groups showed a decreased expression of leptin receptors ObR-b. In our results, the kind of diet for the induction of obesity is relevant for the outcome of the pathological profile.

KEYWORDS:

• Diet induced obesity
• leptin
• heart hypertrophy
• hypercaloric diets
• obesity

Disclosure statement

The authors declare that there is no conflict of interest.

Data availability

The data that support the findings of this study are available on request from the corresponding author, MAE.

Additional information

Funding

This research was partially supported by the Grant number UJAT-2014-IB-42 from Programa de Fomento a la Investigación (PFI-UJAT) and National Council of Science and Technology (CONACYT) [Grant number CB 2013–222290-M] to MAE.