https://orcid.org/0000-0003-1365-3329
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Abstract
Objective
To evaluate the diagnostic and prognostic value of biomarkers and new bioscore in septic patients in intensive care unit (ICU).
Materials and methods
A study was conducted on septic and non-septic patients in ICU. Diagnostic and prognostic values of C-reactive protein (CRP), procalcitonin (PCT), Sequential Organ Failure Assessments (SOFA) score and new bioscore were analysed statistically.
Results
A total of 226 patients were enrolled in the study. In septic patients, PCT, SOFA and bioscore were found significantly increased (p = .007, p = .001 and p = .001, respectively). The AUC value of bioscore was higher than PCT and SOFA in septic patients. SOFA was found to be more significant prognostic marker than bioscore in predicting 28-day mortality. The prognostic value of bioscore and SOFA was similar for predicting 90-day mortality.
Conclusions
The new bioscore formed by combination of CRP, PCT and SOFA score may be useful in early diagnosis of sepsis.
Disclosure statement
The authors declare that there is no conflict of interest.
Author contributions
P. S. designed the study. P. S., T. D., S. A. N. and A. S. researched the data. P. S. and T. D. analysed the data statistically. P. S. and T. D. prepared the manuscript. P. S., T. D., S. A. N. and A. S. reviewed the manuscript. All authors approved the final form of manuscript.