Baicalein maintains redox balance in experimental hyperlipidemic rats

Abstract

Context: An altered lipid profile may lead to the development of CVD.

Objective: We evaluated the protective role of baicalein (BAC) against lipidemic and oxidative stress in hyperlipidemic challenged Wistar rats.

Materials and methods: Male Wistar rats were given a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) to create a hyperlipidemic model. BAC was supplemented to experimental rats (80 mg/kg body weight). Biomarkers of oxidative stress including ROS, FRAP, GSH, PMRS, AGE, MDA, PCO, AOPP, and other parameters (Paraoxonase-1, SGOT, SGPT) including TNF-α and IL-6, were estimated in blood.

Results: Oxidative stress and inflammatory markers were significantly increased in the HFD treated group. BAC treatment protected rats from HFD mediated alterations.

Discussion & conclusion: Our results indicate that baicalein provides protection against hyperlipidemic stress and redox imbalance induced by HFD in rats.

Keywords:

• Hyperlipidaemia
• baicalein
• oxidative stress
• blood
• liver
• rat

Acknowledgement

Dr. D.S. Kothari Post-Doctoral Fellowship scheme of University Grant Commission (UGC), New Delhi, India, is also acknowledged for providing financial support (F(0).4–2/2006 (BSR)/BL/17–18/0381) to Shambhu Sharan Tripathi. The Department of Biochemistry is supported by the FIST grant of DST, New Delhi, and SAP DR SIR from UGC, India.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The information that helps the finding of this study is accessible from the corresponding author upon reasonable request.

Additional information

Funding

This work was supported by a research grant to SIR from SERB-DST, Govt of India [EMR/2016/006470].