LncRNA AK131850 is downregulated in thoracic aortic aneurysm and negatively affects the levels of TGF-β1 in aortic smooth muscle cells

Abstract

This study aimed to investigate the role of lncRNA AK131850 in thoracic aortic aneurysm (TAA). We found that AK131850 was downregulated, while TGF-β1 was upregulated in aortic media specimen of thoracic aortic aneurysm (TAA) patients. In addition, AK131850 and TGF-β1 inversely correlated. Altered expression levels of AK131850 and TGF-β1 distinguished TAA patients from healthy controls. In human aortic smooth muscle cells (HAOSMC), AK131850 overexpression led to downregulated, while AK131850 siRNA silencing led to upregulated TGF-β1. AK131850 overexpression resulted in promoted, while siRNA silencing led to inhibited proliferation of HAOSMC. Therefore, AK131850 is downregulated in thoracic aortic aneurysm and negatively affects the levels of TGF-β1 in aortic smooth muscle cells.

Keywords:

• Thoracic aortic aneurysm
• AK131850
• TGF-β1
• aortic smooth muscle cell

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability

The analysed data sets generated during the study are available from the corresponding author on reasonable request.

Additional information

Funding

This research was supported by the Research Foundation for Advanced Talents of Qingdao Agricultural University (663/1119004).