Association of E-Selectin gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran

Abstract

Background

Adhesion molecules like E-selectin have important role in pathogenesis of atherosclerosis. C1901T and G98T polymorphisms of E-selectin gene and E-selectin serum level may affect the risk of coronary artery disease (CAD).

Methods

A total of 145 normal individuals and 154 patients diagnosed with CAD from the Lur population of Iran undergoing coronary angiography were enrolled. Genetic polymorphisms of E-selectin were determined using PCR-RFLP. Serum level of soluble E-selectin was measured using Elisa.

Results

T allele in C1901T polymorphism was significantly associated with an increased risk of atherosclerosis (P = 0.018). No significant association was observed for G98T polymorphism. The mean serum level of soluble E-selectin in the patient group was significantly higher than the control group (P < 0.001).

Conclusions

Allele type in C1901T polymorphism plays a role in increasing the risk of developing CAD. Furthermore, since serum E-selectin level is associated with systemic inflammation, it contributes to the increased risk of the disease.

Keywords:

• Cardiovascular diseases
• atherosclerosis
• adhesion molecules
• soluble e-selectin
• genetic polymorphisms

Acknowledgements

We acknowledge deputy of research of Lorestan University of Medical Sciences for supporting this project which was an MSc thesis of clinical biochemistry.

Ethics and constant statement

Informed consent was taken from the participants. No diagnostic test or therapeutic intervention was imposed to the participants other than routine medical indications. Privacy and secrecy were regarded. The protocol of this study was approved by Lorestan University of Medical Sciences ethics committee with ethics number IR.LUMS.REC.1396.314.

Disclosure statement

The authors declare no conflict of interest.

Data availability statement

The data that support the findings of this study are available on request from the corresponding author, GS. The data are not publicly available due to their containing information that could compromise the privacy of research participants.

Additional information

Funding

This work was funded by Lorestan University of Medical Sciences with grant number a119.