Molecular docking studies, anti-Alzheimer’s disease, antidiabetic, and anti-acute myeloid leukemia potentials of narcissoside

Abstract

In this research, we explored their capacity for Narcissoside antioxidant and anticholinergic, antidiabetic, and anti-acute myeloid leukaemia. Narcissoside’s antioxidant activities were elucidated by the use of various bioanalytical assays. Narcissoside’s radical scavenging activities were evaluated by DPPH^• and ABTS^•+ scavenging activities. On the other hand, IC₅₀ values were calculated for DPPH^•, and ABTS^•+ scavenging, acetylcholinesterase, and α-glucosidase inhibition effects of narcissoside. IC₅₀ values narcissoside, as 11.54 nM for AChE and 65.58 nM for α-glucosidase were calculated with % Activity-[Inhibitory] graphs. Then, ADME/T analysis of narcissoside molecule was performed to calculate the drug becoming parameters.

Keywords:

• Narcissoside
• acetylcholinesterase
• therapeutic activities
• acute myeloid leukaemia

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data that support the findings of this study are available from the corresponding author, HF, upon reasonable request.