The intrauterine perfusion of granulocyte-colony stimulating factor (G-CSF) before frozen-thawed embryo transfer in patients with two or more implantation failures

Abstract

The objective of this study was to investigate the clinical benefits of intrauterine perfusion with G-CSF in patients undergoing a frozen-thawed embryo transfer (FET) after at least two previous implantation failures. This was a prospective, randomized, single-blind study. The intervention group received an intrauterine infusion of G-CSF whereas the placebo group was given an intrauterine infusion of physiological saline before embryo transfer. A third (control) group did not receive an intrauterine infusion prior to embryo transfer. The clinical pregnancy rates of both the intervention and placebo group were significantly higher than that in the control group (p < 0.05). But the miscarriage rates of the G-CSF were significantly lower than those of the other two groups (p < 0.05). The intrauterine infusion of G-CSF before frozen-thawed embryo transfer significantly reduced miscarriage rates and improve the live birth rates. While intrauterine perfusion with physiological saline did not reduce miscarriage rates.

Keywords:

• G-GSF
• repeated implantation failure
• IVF
• intrauterine infusion

Acknowledgements

The authors thank all their colleagues and teachers in the Reproductive Medicine Center, Liuzhou Maternal and Child Healthcare Hospital.

Disclosure statement

The authors declare that they have no conflict of interest.

Data availability statement

The data analysed during the current study are available from the Liuzhou Maternity and Child Healthcare Hospital in Guangxi.

Additional information

Funding

This work was supported by Guangxi natural science foundation [2019JJB140179], the Guangxi Zhuang Autonomous Region Health and Family Planning Research Project [Z2015177], the Guangxi Liuzhou Science Research and Technology Development Project [2016G020216].