ABSTRACT
Objectives
To evaluate and compare the retention rate, safety, and efficacy of two different lamotrigine (LTG) titration protocols for newly diagnosed epilepsy patients.
Methods
We retrospectively evaluated newly diagnosed epilepsy patients taking LTG from January 2012 to December 2021. In one titration protocol, LTG was taken once daily; in the other, LTG was taken twice daily. Clinical characteristics, seizure outcomes, adverse effects and patient retention rates were evaluated.
Results
A total of 193 patients were included. There was no significant difference in seizure outcomes or adverse effects between patients treated with LTG once daily and twice daily. However, the retention rates were significantly higher in the once-daily group than in the twice-daily group (73.03% and 55.77%, respectively).
Conclusion
The effectiveness and safety of LTG were not significantly different between the two different LTG titration protocols groups. However, the retention rate of the patients treated with LTG once daily was higher than that of the patients treated with LTG twice daily.
Declaration of interest
The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Author contributions
N Zhang: Conceptualization, Methodology, Software, Investigation, Writing -Original Draft. D Yang: Investigation, Validation, Formal analysis, Software. C Niu: Investigation, Validation, Formal analysis. P Li: Validation, Formal analysis. H Wang: Validation, Formal analysis. X Li: Supervision, Data Curation, Writing - Review & Editing. W Jing: Supervision, Resources, Writing - Review & Editing, Data Curation. All authors read and approved the final version of the manuscript for publication.
Supplementary material
Supplemental data for this article can be accessed online at https://doi.org/10.1080/14737175.2022.2155141