Abstract
Background: It is well known that human milk oligosaccharides play an important role as prebiotics, anti-inflammatory, and anti-infective agents. In the last few years, several studies have been performed using specific oligosaccharides, such as 2′-fucosyllactose and 6′-sialylactose, to evaluate their biological functions.
Objectives: The aim of the present study is to evaluate the anti-adhesive effect of the above oligosaccharides on Escherichia coli and Salmonella fyris.
Methods: Adhesion experiments were performed in the presence of 2′-fucosyllactose and 6′-sialyllactose as potential inhibitors of Escherichia coli and Salmonella fyris adhesion to Caco-2 cells. The oligosaccharides were used at different concentrations and the adhesion experiments were performed in triplicate and repeated at least three times.
Results: A significant reduction of Escherichia coli adhesion was observed in the presence of 2′-fucosyllactose and 6′-sialyllactose at the human milk concentration. On the contrary, no positive effects were observed in both oligosaccharides on Salmonella firis.
Conclusions: Our results suggest that the supplementation in infant formulas of 2′-fucosyllactose and 6′-sialyllactose, actually commercially available and absent in cow milk, could play positive effects in artificially fed infants.
Acknowledgements
The authors thank INALCO, SpA, Milan, Italy for the generous gift of 2′-FL and 6′-FL.
Disclosure statement
The authors declare no conflict of interest.