The association between adipocytokines and glycemic control in women with gestational diabetes mellitus

Abstract

Objective: To evaluate the relationship between adipocytokines and glycemic control.

Study design: Prospective observational trial of gestations with gestational diabetes mellitus (GDM). Fasting glucose (FG), insulin, adiponectin, leptin, chemerin, retinol-binding protein 4 (RBP-4), osteocalcin, and resistin were measured. HomeOstasis model assessment of insulin resistance (HOMA-IR) and QUantitative insulin sensitivity ChecK Index (QUICKI) were calculated. Women who required medications for glycemic control were compared to women using nutritional therapy only.

Results: Overall, 75 women were included −26 (34.7%) required medications to achieve good glycemic control. Factors associated with poor control are as follows: low resistin (aOR 0.84), HOMA-IR (aOR 1.96), QUICKI (aOR 0.62), first trimester FG (aOR 1.43), and maternal age (aOR 1.26). HOMA-IR and QUICKI performed highest for prediction. Resistin, first trimester FG, maternal age, and QUICKI had an AUC of 0.878, sensitivity and specificity of 87.5% for the prediction of the need for medications.

Conclusions: Low resistin is associated with poor control. A model utilizing maternal age, first trimester fasting glucose, and first visit QUICKI yields good predictability.

Keywords:

• Adipocytokines
• gestational diabetes mellitus
• glycemic control
• therapy intervention

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was funded by the Young Researcher Grant (7000 USD) from the Error! Hyperlink reference not valid., Petah Tikva, Israel.