Effectiveness of theophylline administration in neonates with perinatal asphyxia: a meta-analysis

Abstract

Aim

To evaluate the effects of prophylactic theophylline in renal function and survival rates of asphyxiated newborns.

Methods

Medline, Scopus, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov and Google Scholar databases were systematically searched. All randomized controlled trials evaluating the efficacy of theophylline in the prevention of perinatal asphyxia were selected.

Results

A total of seven studies were included with a total of 458 asphyxiated neonates. Incidence of acute kidney injury was significantly lower in neonates receiving theophylline (OR: 0.24, 95% CI: [0.16, 0.36]), while mortality rates were similar between the two groups (OR: 0.86, 95% CI: [0.46, 1.62]). Theophylline administration was associated with significantly decreased serum creatinine levels (MD: −0.57 mg/dl, 95% CI: [−0.68, −0.46]) and elevated glomerular filtration rate (MD: 13.79 ml/min/1.73 m², 95% CI: [11.91, 15.68]) in the third day of life. Theophylline also lead to lower β2-microglobulin levels, higher urine output and negative fluid balance.

Conclusions

The present findings suggest the effectiveness of theophylline in ameliorating renal function of asphyxiated neonates. Future large-scale trials should assess potential long-term adverse outcomes in clinical practice.

Keynotes

• Asphyxia is a major cause of acute kidney injury in neonates

• Acute kidney injury is associated with adverse clinical outcomes in asphyxiated neonates.

• Theophylline administration leads to significantly lower incidence of acute kidney injury in asphyxiated neonates.

Keywords:

• Acute kidney injury
• meta-analysis
• perinatal asphyxia
• theophylline
• neonate

Disclosure statement

The authors declare that they have no conflict of interest.

Author contributions

Ioannis Bellos designed data collection, carried out the statistical analyses and drafted the initial manuscript. Aakash Pandita conceived the idea, contributed to data extraction and wrote the manuscript. Monika Yaccha supervised study design and data collection and critically revised the manuscript.