Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia

Abstract

Introduction

Preeclampsia has the highest rate of obstetric morbidity and mortality.

Methods

We recruited 21 women with preeclampsia and 27 women with uncomplicated pregnancies. We used a quantitative protein macroarray that allowed for analysis of 40 proteins.

Results

We found a statistically significant increase in the concentration of DR3, LIF and a significant decrease of VEGF, PlGF, syndecan-4 and galectin-2, in the plasma of women with preeclampsia.

Conclusions

There are no previous studies assessing syndecan 4, galectin 2, and DR3 concentrations in women with preeclampsia; Our results indicate these proteins are new factors that play important roles in the immunological pathomechanism of preeclampsia.

Keywords:

• Angiogenesis
• apoptosis
• cytokine
• immune response
• inflammatory factors
• placenta
• preeclampsia

Disclosure statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Additional information

Funding

This work was supported by grant numbers: 2015/19/N/NZ5/01434 from National Science Center and N/ST/MN/17/001/1133 from Polish Ministry of Science and Higher Education. Study sponsored by a Polpharma Scientific Foundation. Supported by the Foundation for Polish Science (FNP). The manuscript has undergone professional English editing by Elsevier editors.