Association of physical activity and trajectories of physical activity with cardiovascular disease

ABSTRACT

Introduction

Prolonged sedentary life existence is associated with increased incidence of cardiovascular disease (CVD), coronary heart disease (CHD), obesity, type 2 diabetes mellitus (T2DM), hypertension, heart failure (HF), and all-cause mortality. On the contrary, regular exercise is known from antiquity to be associated with beneficial cardiovascular (CV) effects and decreased mortality.

Areas covered

The cardiovascular (CV) benefits of exercise have been confirmed by many studies, but the trajectories of the different modes of PA are not well recognized. In order to examine the different modalities of exercise and its long-term trajectories, a Medline search of the English literature was conducted between 2015 and 2022 and 60 pertinent papers were selected for review.

Expert opinion

Careful review of the selected papers showed that the beneficial CV effects of PA are mediated through several favorable modifications of molecular and clinical factors. Also, any type of physical activity in conjunction with lifestyle adjustments is associated with decreased incidence of CVD, CHD, obesity, T2DM, hypertension, HF, and all-cause mortality. In addition, the long-term trajectories regarding the duration and the level of exercise are associated with greater beneficial CV effects, with even the resumption of discontinued exercise can lead to beneficial CV effects.

KEYWORDS:

• Exercise
• exercise trajectories
• CV benefits
• modes of exercise

Article highlights

• Sedentary existence is bad and associated with increased incidence of CVD and death

• In contrast, regular PA is associated with decreased incidence of CVD and death

• Exercise trajectories are associated with maintenance of good health and decrease in cardiovascular complications

• Any level of exercise is healthy, but vigorous exercise provides the best CV benefits

• Sedentary subjects and subjects with existing CHD embarking suddenly, on vigorous PA could rarely, sustain serious or lethal cardiovascular complications. Overall, PA is safe and recommended

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership, or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers in this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.