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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 5
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Research Articles

Antiproliferative and cytotoxic secondary metabolites from fruits of Leplaea mayombensis

Sidjui Sidjui LazareInstitute of Medical Research and Medicinal Plant Studies, Yaoundé, Cameroon;Faculty of Sciences, Department of Organic Chemistry, TWAS Research Unit (TRU) of University of Yaounde I, Yaoundé, Cameroon;H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, PakistanCorrespondence[email protected]
,
Soh DésiréDepartment of Chemistry, Higher Teacher Training College, The University of Bamenda, Bambili-Bamenda, Cameroon
,
Dameue Tegang Joel EbenezerFaculty of Sciences, Department of Organic Chemistry, TWAS Research Unit (TRU) of University of Yaounde I, Yaoundé, Cameroon
,
Happi Tchakounté BriceDepartment of Chemistry, Higher Teacher Training College, The University of Bamenda, Bambili-Bamenda, Cameroon
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Toghueo Kouipou Rufin MarieLaboratory for Phytobiochemistry and Medicinal Plant Study, Antimicrobial and Biocontrol Agent Unit, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon
,
Wembe Ngouonpe AlainDepartment of Chemistry, Higher Teachers’ Training College, University of Yaoundé I, Yaoundé, Cameroon
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Shaiq Ali MuhammadH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, PakistanCorrespondence[email protected]
&
Folefoc Ngosong GabrielFaculty of Sciences, Department of Organic Chemistry, TWAS Research Unit (TRU) of University of Yaounde I, Yaoundé, CameroonCorrespondence[email protected]
 show all
Pages 635-641 | Received 17 Sep 2017, Accepted 29 Oct 2017, Published online: 13 Nov 2017
 
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Abstract

Two new seco-lanostane-type triterpenes, named mayomlactones A (1) and B (2) were isolated from the fruits of Leplaea mayombensis together with 10 known compounds (3–12). Structures of the new compounds were elucidated by extensive spectroscopic studies. Except compounds 11 and 12, all the other chemical compounds are newly reported from Leplaea genus. From the results of this investigation, compounds 1–10 were examined for antiproliferative activity against HeLa cells as well as cytotoxicity against 3T3 cell line. Compounds 3 and 4 showed moderate antiproliferative activity with IC50 values of 10.4 ± 0.1 and 18.6 ± 0.2 μM, respectively. On the other hand, compounds 1, 4 and 9 showed weak cytotoxicity with IC50 values 44.1 ± 0.5, 55.8 ± 0.7 and 55.1 ± 0.5 μM. Overall, none of the tested compounds showed good selectivity (SI ranging from 0.51 to 3.06) but high toxicity against the 3T3 cell line.

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