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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 5
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Research Articles

Chemical constituents from the fruits of Psoralea corylifolia and their protective effects on ionising radiation injury

Jie DuTianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Chun-Hua WangTianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China;College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Jing YangTianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Xin HeInstitute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, China
,
Xiao-Liang HanDepartment of Anesthesiology, North China University of Science and Technology Affiliated Hospital, Tangshan, China
,
Cong-Cong LiTianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Xin ChaiTianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCorrespondence[email protected]
,
Yue-Fei WangTianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Yan ZhuTianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
&
Zheng LiCollege of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCorrespondence[email protected]
 show all
Pages 673-680 | Received 08 Aug 2017, Accepted 09 Nov 2017, Published online: 20 Nov 2017
 
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Abstract

Two new flavonoids, corylifol F (1) and corylifol G (2), together with 19 known compounds, were isolated from the fruits of Psoralea corylifolia L.. The structures of these compounds were determined by interpretation of spectroscopic data and comparison with literature properties. The radioprotective effects of the isolated compounds against ionising radiation damage were also evaluated in vitro. The results showed that corylifol A exhibited radioprotective effects in both HBL-100 and MCF-7 cells, while psoralen, isopsoralen, corylifol C and bakuchiol showed obvious selective action to protect HBL-100 cells against damage caused by ionising radiation.

Acknowledgements

The authors thank Prof. Tian-Xiang Li for authenticating the plant material and Harmonia Testing Technology (Tianjin) Limited Company for NMR measurements.

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