12-Epi-9-deacetoxyxenicin, new cytotoxic diterpenoid from a Bornean soft coral, Xenia sp.

Abstract

One new compound, 12-epi-9-deacetoxyxenicin (1) along with a hydroperoxide product, 12-epi-9-deacetoxy-8-hydroperoxyxenicin (2) and two known sesquiterpenoids (3–4) were isolated from a population of Bornean soft coral Xenia sp. The structures of these secondary metabolites were elucidated based on their spectroscopic data. Compounds 1 and 2 showed cytotoxic activity against ATL cell line, S1T. In addition, compound 3 exhibited hyphal inhibition of Lagenidium thermophilum.

Keywords:

• Soft coral
• Xenia sp.
• xenicane
• diterpene
• adult T-cell leukemia

Acknowledgement

The authors would like to acknowledge Prof. Dr Tatsufumi Okino and Ms. Liang Wei from Hokkaido University for SciFinder search, Prof. Dr Kishio Hatai (Universiti Malaysia Sabah) for providing fungal strains and Prof. Dr Naomichi Arima (Kagoshima University) for providing ATL cancer cell line, S1T.