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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 12
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Short Communication

Report of in vitro antileishmanial properties of Iberian macroalgae

Carolina Bruno de SousaCentre of Marine Sciences, University of Algarve, Faro, Portugal
,
João Henrique G. LagoInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, São Paulo, Brazil
,
Jorge MacridachisCentre of Marine Sciences, University of Algarve, Faro, PortugalORCID Iconhttp://orcid.org/0000-0002-3081-8378
ORCID Icon,
Marta OliveiraCentre of Marine Sciences, University of Algarve, Faro, Portugal;Global Health and Tropical Medicine Centre, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
,
Luis BritoCentre of Marine Sciences, University of Algarve, Faro, Portugal
,
Catarina Vizetto-DuarteCentre of Marine Sciences, University of Algarve, Faro, Portugal
,
Cláudia FlorindoPrograma de Medicina Regenerativa, Departamento de Ciências Biomédicas e Medicina, UAlg, Faro, Portugal;Centro de Investigação Biomédica, University of Algarve, Faro, Portugal
,
Sarah HendrickxFaculty of Pharmaceutical, Department of Biomedical Sciences, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium
,
Louis MaesFaculty of Pharmaceutical, Department of Biomedical Sciences, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium
,
Thiago MoraisInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, São Paulo, Brazil
,
Miriam UemiInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, São Paulo, Brazil
,
Luís NetoFaculdade de Ciências e Tecnologia, University of Algarve, Faro, PortugalORCID Iconhttp://orcid.org/0000-0003-1834-6459
ORCID Icon,
Lídia DionísioFaculdade de Ciências e Tecnologia, University of Algarve, Faro, Portugal
,
Sofia CortesGlobal Health and Tropical Medicine Centre, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
,
Luísa BarreiraCentre of Marine Sciences, University of Algarve, Faro, PortugalORCID Iconhttp://orcid.org/0000-0002-4077-855X
ORCID Icon,
Luísa CustódioCentre of Marine Sciences, University of Algarve, Faro, Portugal
,
Fernando AlberícioInstitute for Research in Biomedicine, Barcelona Science Park, Barcelona, Spain
,
Lenea CampinoGlobal Health and Tropical Medicine Centre, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
&
João VarelaCentre of Marine Sciences, University of Algarve, Faro, PortugalCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3101-693X
ORCID Icon show all
Pages 1778-1782 | Received 17 Nov 2017, Accepted 25 Jan 2018, Published online: 09 Feb 2018
 
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Abstract

Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.

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