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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 3
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Short Communication

Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage

Rebeca P. MedinaNúcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE), Departamento de Química Orgânica, Instituto de Química, UNESP - Univ. Estadual Paulista, Araraquara, Brazil
,
Angela R. AraujoNúcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE), Departamento de Química Orgânica, Instituto de Química, UNESP - Univ. Estadual Paulista, Araraquara, Brazil
,
Raymond J. AndersenDepartment of Chemistry and Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada
,
Marcos A. SoaresInstituto de Biociências, Universidade Federal de Mato Grosso, Cuiabá, Brazil
,
Fabio de A. SilvaInstituto de Biociências, Universidade Federal de Mato Grosso, Cuiabá, Brazil
&
Dulce H. S. SilvaNúcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE), Departamento de Química Orgânica, Instituto de Química, UNESP - Univ. Estadual Paulista, Araraquara, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1516-7765
ORCID Icon
Pages 443-446 | Received 24 Aug 2017, Accepted 11 Mar 2018, Published online: 26 Mar 2018
 
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Abstract

Endophytic fungi were isolated from red alga Asparagopsis taxiformis - Falkenbergia stage, collected from the Brazilian coast, and were identified as Annulohypoxylon stygium (AT-03) and A. yungensis (AT-06) based on their macro/micromorphological and molecular features. Bioassay-guided fractionation of the EtOAc extract from laboratory cultures of both strains yielded known compounds pyrogallol from A. stygium, (3R)-scytalone and (3R,4R)-4-hydroxy-scytalone from A. yungensis. Pyrogallol was active against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli strains. An inactive fraction from A. stygium afforded two additional compounds, (3R,4R)-3,4,5-trihydroxy-1-tetralone and tyrosol. Optically active compounds had their stereochemistry determined by circular dichroism (CD) spectroscopy.

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