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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 8
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Research Articles

Synthesis, characterization, and biological evaluations of some steryl 2-methoxybenzoates as anticancer agents

, , , , , , , & show all
Pages 1101-1105 | Received 14 Nov 2017, Accepted 23 Mar 2018, Published online: 30 Mar 2018
 

Abstract

Using cholesterol, stigmasterol and sitosterol as starting materials, a series of 7-subsitituted-ster-3-yl 2-methoxybenzoate analogs were prepared through reacting with 2-methoxybenzoyl chloride and introducing some function groups, such as carbonyl, hydroxyl and various thiosemicarbazones, at 7-position of steroidal nucleus. The structures of these new compounds were characterized by IR, NMR and HRMS. Their antiproliferative activities were evaluated by using several types of cancer cells. Interestingly, the compounds displayed potent antiproliferative activity against CNE-2 (nasopharyngeal carcinoma cell lines), BEL-7402 (human liver cancer cell lines) and HepG2 (human liver cancer cell lines), suggesting that they have potential to be drug candidates for cancer treatment.

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