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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 8
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Research Articles

Two pairs of phenolic enantiomers from the leaves of Eucommia ulmoides Oliver

Jian-Kun YanSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin, P.R. China
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Xu-Liu ShiSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin, P.R. China
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Paul Owusu DonkorSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin, P.R. China
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Xiu-Mei GaoSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin, P.R. China
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Li-Qin DingSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin, P.R. ChinaCorrespondence[email protected]
&
Feng QiuSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China;Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin, P.R. ChinaCorrespondence[email protected]
Pages 1162-1168 | Received 20 Jan 2018, Accepted 03 Apr 2018, Published online: 04 May 2018
 
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Abstract

Two pairs of new phenolic enantiomers, (+)-eucophenolic A (1a), (-)-eucophenolic B (1b), (-)-eucophenolic C (2a), (+)-eucophenolic D (2b) were isolated from the leaves of Eucommia ulmodies Oliver by chiral enantiomeric resolution. Their structures were elucidated based on extensive spectroscopic analysis. The absolute configurations of 1a/1b and 2a/2b were determined by empirical method and the calculated ECD and OR. All compounds were tested for Hep G2 tumour cell lines. However, no compounds showed potential cytotoxic activities against Hep G2 in vitro.

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