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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 18
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Research Articles

Antihyperlipidemic glycosides from the root bark of Lycium chinense

Hui ChenCollaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China;School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, ChinaCorrespondence[email protected]
,
Yu-Jie LiSchool of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China
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Yan-Jun SunCollaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China;School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
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Xiao-Kun LiCollaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China;School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, ChinaCorrespondence[email protected]
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Gong Jian-HongCollaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China;School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
,
Ya WuCollaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China;School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
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Fang-Yi SuCollaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China;School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
,
Kun DuCollaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China;School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
,
Yan-Li ZhangCollaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China;School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
&
Wei-Sheng FengCollaborative Innovation Center for Respiratory Disease Diagnosis, Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China;School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
 show all
Pages 2655-2661 | Received 22 Jan 2018, Accepted 13 Apr 2018, Published online: 08 May 2018
 
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Abstract

Three new glycosides (1–3), together with six known ones (4–9), were isolated from the root bark of Lycium chinense. Their structures were elucidated on the basis of MS and NMR spectroscopic data. Five compounds (3, 5, 6, 8, and 9) exhibited potent antihyperlipidemic activities in HepG2 cells as assessed by Oil Red O staining and significant inhibition of intracellular triglyceride (TG) levels, whereas two compounds (5 and 9) significantly reduced total cholesterol (TC) levels.

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