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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 9
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Research Articles

Two new isochromane derivatives penisochromanes A and B from ascidian-derived fungus Penicillium sp. 4829

Shah-Iram NiazSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, China
,
Panpan ZhangSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, ChinaORCID Iconhttp://orcid.org/0000-0003-0081-7320
ORCID Icon,
Hongjie ShenSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, China
,
Jing LiSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, China
,
Bin ChenSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, China
,
Senhua ChenSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, China;Key Laboratory of Functional Molecules from Oceanic Microorganisms, Department of Education of Guangdong Province, Sun Yat-Sen University, Guangzhou, China;South China, Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou, ChinaCorrespondence[email protected]
,
Lan LiuSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, China;Key Laboratory of Functional Molecules from Oceanic Microorganisms, Department of Education of Guangdong Province, Sun Yat-Sen University, Guangzhou, China;South China, Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou, ChinaCorrespondence[email protected]
&
Jianguo HeSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, China;South China, Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou, China
 show all
Pages 1262-1268 | Received 12 Feb 2018, Accepted 24 Apr 2018, Published online: 04 May 2018
 
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Abstract

Seven polyketides, including two new isochromanes, penisochromanes A and B (1 and 2), as well as five known compounds were obtained from an ascidian-derived fungus Penicillium sp. 4829. Their structures were identified by extensive spectroscopic analyses. The structures of compounds 1 and 3 were further determined by the X-ray crystallography. Compounds 1 and 2 were the first example of isochromane with three adjacent oxy substituents in natural source. Compound 4 exhibited selective activities against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, with MIC values 6.25 and 12.5 μM, respectively.

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